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- W2387191745 abstract "MicroRNAs(miRNAs) are a class of conservative endogenous non-coding RNAs with the length of 18-25 nucleotides,which can degrade mRNA and inhibit protein translation by binding to the target mRNA.Growing evidence has shown that miRNAs play crucial roles in cell proliferation,differentiation,development and apoptosis.miR-143 and miR-145 have been identified to be down-regulated in a variety of tumors,including colorectal cancer,breast cancer,prostate cancer,bladder cancer,gastric cancer,lung cancer,esophageal cancer,cervical cancer,pancreatic cancer,nasopharyngeal carcinoma,ovarian cancer,osteosarcoma,liposarcoma,Ewing's sarcoma,and leukemia,with the function of inhibiting cell proliferation,invasion and metastasis,promoting cell apoptosis,and increasing sensitivity to anti-tumor drugs by binding to the target genes,such as KRAS,c-Myc,and ERK5.Based on these backgrounds,the combined treatment of anti-tumor agents and miR-143 and/or miR-145 is a novel potential approach for chemotherapy." @default.
- W2387191745 created "2016-06-24" @default.
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- W2387191745 date "2013-01-01" @default.
- W2387191745 modified "2023-09-23" @default.
- W2387191745 title "Advances in miR-143,miR-145 and tumor research" @default.
- W2387191745 hasPublicationYear "2013" @default.
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