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- W2387203487 abstract "Aim:A multiple-dose pharmacokinetic-pharmacodynamic model was proposed to study the relationship between pharmacokinetic profile and insulin sensitivity index of telmisartan.Methods:Model of insulin-resistance was developed by feeding high-fat and high-fructose diet to SD rats in two successive months.The insulin-resistance rats were then randomly divided into telmisartan(4 mg/(kg ·day)),telmisartan(8 mg/(kg ·day)) and control groups.The insulin-resistance rats received repeated gastric dosing of telmisartan in 45 days.The rat plasma samples were collected at predetermined intervals,and determined for telmisartan blood levels.Meanwhile,rat blood glucose and blood insulin levels were determined before dosing and at days 9,18,27,36,and 45 after dosing.Insulin sensitivity index was used as the quantitative parameter for measuring the efficacy.The relationship of drug exposure to insulin sensitivity index was modeled by the suggested pharmacokinetic-pharmacodynamic model.Results:There was no considerable telmisartan accumulation in the rats after oral multiple-dosing administration.No significant difference in the pharmacokinetic parameters between the first and the final administration was found.AUC50 of insulin sensitivity index at 4 mg/(kg ·day) and 8 mg/(kg ·day) were 2 886.0 ng ·day/mL and 3 218.9 ng ·day/mL,respectively.Conclusion:Our results indicates that there is a long and slow period in the improvement of telmisartan to insulin resistance and that this effect is well correlated with the drug exposure index instead of drug concentration." @default.
- W2387203487 created "2016-06-24" @default.
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- W2387203487 date "2008-01-01" @default.
- W2387203487 modified "2023-09-23" @default.
- W2387203487 title "Pharmacokinetic-pharmacodynamic model of telmisartan in insulin-resistance rats" @default.
- W2387203487 hasPublicationYear "2008" @default.
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