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- W2387211742 abstract "Purpose To investigate the expression of Ataxin-3 in human gastric cancer tissue and to explore the role of Ataxin-3 in the carcinogenesis and development of gastric cancer and relationship with clinicopathologic features.Methods The expression patterns of Ataxin-3 in gastric cancer(n = 265),noncancerous gastric mucosa(n = 209),low grade intraepithelial neoplasia(LGIN)(n = 86) and high grade intraepithelial neoplasia(HGIN)(n = 75) tissues of patients were determined by immunohistochemistry.Statistical analysis was used to determine the correlation between Atasin-3 expression with the clinicopathologic features.Results The expression of Ataxin-3 in the gastric carcinoma was lower than that in noncancerous gastric mucosa and has significant difference between gastric carcinoma and LGIN(P 0.001),but no significant difference was observed between gastric carcinoma and HGIN(P 0.05).The expression of Ataxin-3 were correlated with Lauren classification,histologic differentiation,distant metastasis and p53 expression(P 0.05).Conclusion Ataxin-3 may play an important role in the carcinogenesis and progression of gastric cancer." @default.
- W2387211742 created "2016-06-24" @default.
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- W2387211742 date "2013-01-01" @default.
- W2387211742 modified "2023-09-24" @default.
- W2387211742 title "Ataxin-3 expression in gastric cancer and its clinicopathologic significance" @default.
- W2387211742 hasPublicationYear "2013" @default.
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