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- W2387213901 abstract "Objective To investigate the expression of matrix metalloproteinase suppressor gene RECK and its relationship with matrix metalloproteinase-9(MMP-9) and MMP-2 in villi in patients with early spontaneous abortion(ESA).Methods The expression of RECK,mRNA and protein of matrix metalloproteinases MMP-9 and MMP-2 in villi of ESA patients(abortion group,n=20) and normal first trimester pregnant women(control group,n=20) was detected by semi-quantitative RT-PCR,Western blotting,respectively.The correlations between the expression of RECK and the expression of MMP-2,MMP-9 were analyzed by Pearson test.Results ①The expression of MMP-9 and MMP-2 mRNA was significantly lower in villi of the abortion group compared with that of the control group(P0.05).The expression of RECK mRNA increased significantly in villi of the abortion group(P0.05);②Western blotting analysis demonstrated that the expression of MMP-9 and MMP-2 protein in villi of the abortion group was significantly lower than that of the control group(P0.05).The expression of RECK protein in villi was significantly higher in the abortion group than in the normal control group(P0.05);③The expression of RECK protein in villi of first trimester had significant negative-correlation with that of MMP-2 and MMP-9.Conclusion The increase in the expression level of RECK inhibited the activation of MMP-9 and MMP-2,and resulted in a decrease in the trophoblastic invasion of human placenta,which might be correlated with occurrence of first trimester spontaneous abortion." @default.
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- W2387213901 date "2010-01-01" @default.
- W2387213901 modified "2023-09-28" @default.
- W2387213901 title "Expression of matrix metalloproteinase suppressor gene RECK in villi of early spontaneous abortion and its significance" @default.
- W2387213901 hasPublicationYear "2010" @default.
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