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- W2387232212 abstract "Objective To evaluate the effect of bevacizumab(Avastin)on healing rate of corneal epithelial defect and corneal morphological structure in normal rats.Methods Healthy female SD rats were randomly divided into 2 groups,the defect group and control group.The corneal epithelial defect models were made in defect group,which was subdivided into experimental group A and control group A,4 rats(8 eyes)in each group.Rats in control group were subdivided into experimental group B and control group B,2 rats(4 eyes)in each group.The 5 g·L-1 Avastin eye drop was given to both eyes of rats in experimental groups,and normal sodium was given to rats in control groups.Healing of corneal epithelial defect was observed by fluorescence staining under slit lamp at 12 hours,18 hours,24 hours and 36 hours after modeling in group A until complete healing of epithelial defect.After continuously treating with eye dropping for 7 days,rats in group B were taken corneal histopathologic observation and transmission light microscope examination.Results Slit lamp observation showed that corneal healing rate was consistent in experimental group A and control group A during 24 hours,the corneal epithelium all healed at 36 hours.The healing rate of corneal epithelial defect showed no significant difference between experimental group A and control group A at 12 hours,18 hours and 24 hours(all P0.05).After eye dropping for 7 days in rats of control group,the corneal histological structure and ultramicrostructure were normal without the inflammatory cell infiltration in all corneas of experimental group B compared with control group B.Conclusion There was no effect on the healing rate of rat corneal epithelium and corneal structure after short-term ocular application of 5 g·L-1 Avastin." @default.
- W2387232212 created "2016-06-24" @default.
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- W2387232212 date "2010-01-01" @default.
- W2387232212 modified "2023-09-23" @default.
- W2387232212 title "Effect of Avastin on corneal structure and healing rate of corneal epithelial defect in rats" @default.
- W2387232212 hasPublicationYear "2010" @default.
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