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- W2387235970 abstract "Objective To evaluate the efficacy of ganglioside on treatment of severe hand-foot-mouth disease(HFMD)in children,and effect on serum neuron-specific enolase(NSE)as well as plasma S-100βprotein levels.Methods One hundred and forty cases of severe HFMD patients in a hospital from April 2011 to June 2014 were randomly divided into routine therapy group and trial group,and 30 healthy children who received physical examination in outpatient department during the same period were selected as control.Children in routine therapy group were given antiviral and intracranial decompression therapy;trial group were administered ganglioside in addition to routine therapy,levels of NSE and S-100βprotein levels of 3 groups,as well as clinical efficacy between routine therapy group and trial group were compared.Results Total efficacy rate of trial group was significantly higher than routine therapy group(91.43%[64/70]vs 78.57%[55/70],χ2=4.54,P0.05).The levels of NSE and S-100βprotein in children with severe HFMD were significantly higher than control group([17.63±4.21)μg/L vs[8.79±2.12]μg/L;[492.05±119.33]ng/L vs[296.35±91.02]ng/L,both P0.01).NSE and S-100βprotein levels of routine therapy group and trial group before treatment were not significantly different(both P0.05);after 10-day treatment,NSE and S-100βprotein levels of both groups were lower than before treatment(both P0.01),the decreasing level of NSE and S-100βprotein in trial group were both higher than routine therapy group([10.18±2.36]μg/L vs[5.87±3.03]μg/L;[247.55±64.64]ng/L vs[113.97±43.44]ng/L)(both P0.01).Conclusion Ganglioside has obvious therapeutic efficacy on severe HFMD in children,and can effectively reduce brain damage markers NSE and S-100βprotein." @default.
- W2387235970 created "2016-06-24" @default.
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- W2387235970 date "2015-01-01" @default.
- W2387235970 modified "2023-09-24" @default.
- W2387235970 title "Clinical efficacy of ganglioside on treatment of severe hand-foot-mouth disease and changes in neuron-specific enolase and S-100β protein" @default.
- W2387235970 hasPublicationYear "2015" @default.
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