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- W2387240254 abstract "OBJECTIVE To evaluate the macrolides induced-resistance of Chlamydia trachomatis and the molecular mechanisms of the resistance.METHODS The MICs of erythromycin,josamycin and azithromycin against Chlamydia trachomatis were firstly detected,then the Chlamydia trachomatis was kept on passage in medium and exposed to the three antimicrobial agents in a final concentration of 1/2 MIC.The induced-resistance standard was defined as:posterior MICs≥ 4-fold of the initial.Ribosomal protein L4 and 23S rRNA gene for the strains before and after being induced were analyzed.RESULTS Thirteen clinical strains were studied.The MICs of all the strains after being induced for 16-20 passages increased 4-to 16-fold than the initial,respectively.Mutations of G274A,C276T,C339T,C466G in ribosomal protein L4 and A2131T,C2452A in 23S rRNA were detected in all strains both before and after being induced,while A2059G,A2057G,T2611C and 2093T in 23S rRNA appeared only after being induced.CONCLUSION Macrolides resistance of Chlamydia trachomatics can be induced by exposure to sub-inhibitory concentration of the antimicrobial agents.Mutations in ribosomal protein L4 and mutations of A2131T,C2452A in 23S rRNA are irrelevant to the macrolides induced-resistance,while mutations of A2059G,A2057G,T2611C,2093T in 23S rRNA are colosely correlated to the resistance in Chlamydia trachomatis clinical strains." @default.
- W2387240254 created "2016-06-24" @default.
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- W2387240254 date "2010-01-01" @default.
- W2387240254 modified "2023-09-28" @default.
- W2387240254 title "Macrolides resistance of Chlamydia trachomatis can be induced by exposure to sub-inhibitory concentration of antimicrobial agents in vitro" @default.
- W2387240254 hasPublicationYear "2010" @default.
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