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- W2387244920 abstract "Objective: To study the effect of nordihydroguaiaretic acid(NDGA) on the proliferation of MCF-7 cell line and its regulation on the expression of ERα and ERβ mRNA.Methods: Human breast cancer cell line MCF-7 was treated with different concentrations of NDGA(10,20,50,100 μmol/L) for 3 days.The proliferative status was assayed by MTT and the mRNA levels determined by real-time quantitative PCR.Results: NDGA displayed an inhibitory effect on the growth of MCF-7 cells.NDGA may increase the levels of ERβ mRNA in a dose-dependent manner.The levels of ERα mRNA in MCF-7 cells could be increased by lower concentrations of NDGA,but decreased by higher concentrations of NDGA.Conclusions: The results suggest that NDGA might serve as a potential selective estrogen receptor modulator(SERMs) for the prevention and treatment of cancer." @default.
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- W2387244920 date "2007-01-01" @default.
- W2387244920 modified "2023-09-26" @default.
- W2387244920 title "Influence of nordihydroguaiaretic acid on the growth and ERα,ERβ mRNA levels of human breast cancer cells" @default.
- W2387244920 hasPublicationYear "2007" @default.
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