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- W2387260483 abstract "To detect the expression of DNA repair enzymes:MGMT,DNA PKcs and Ku in lung cancer and normal tissues to evaluate their roles in lung cancer progression. Immunohistochemical method(LSAB) was used to detect the expression of DNA repair enzymes and P53 in 44 lung cancers. Their expression was also detected in histological normal lung tissue from the same patient. 10 patients of lung benign pathological changes are investigated at the same time for comparison. The expression of MGMT was induced to increase during cancer progression,but the expression of other enzymes decreased. There was a trend in cancer tissues to be significantly lower than benign pathological changes to the three enzymes. A significant correlation was found between the degree of expression of DNA PKcs and Ku . The average score of MGMT expression in P53+group is significantly lower than P53-groups. The statistical analysis revealed no correlation between repair enzymes expression and patients ages,sex, histological types and grades. [Conclusion] The changed expression of DNA repair enzymes is at least contributing malignant changes. DNA repair enzymes maybe become the biomarkers of lung cancer susceptibility." @default.
- W2387260483 created "2016-06-24" @default.
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- W2387260483 date "2003-01-01" @default.
- W2387260483 modified "2023-09-28" @default.
- W2387260483 title "Study on the Expression of DNA Repair Enzymes in Lung Cancer Tissues" @default.
- W2387260483 hasPublicationYear "2003" @default.
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