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- W2387271844 abstract "Objective:To study the efficacy of cerivastatin in treatment of hypercholesterolaemia. Methods:After a 5 weeks singleblind runin period (Period A),470 patients were randomised to receive cerivastatin 0.1 mg(n=119),0.2 mg (n=117),0.3 mg(n=116) or placebo(n=118),once daily at bedtime for 8 weeks(Period B).At the end of Period B,patients with a lowdensity lipoprotein cholesterol decrease of ≥20% from baseline continued to receive their randomised dose of cerivastatin or placebo for a further 16 weeks,for an extended assessment of safety.Results:Mean percentage change in lowdensity lipoprotein cholesterol from baseline to the end of Period B in the perprotocol population (the primary efficacy parameter)was -(21.5±13.1)% in the 0.1 mg group,-(25.8±13.0)% in the 0.2 mg group and -(29.5±20.5)% in the 0.3 mg group,compared with a (0.7±13.0)% increase in the placebo group(P=0.0001 for all doses versus placcbo).Conclusion:Cerivastatin was found to have a good efficacy and safety profile in the Chinese hypercholesterolaemic population studied." @default.
- W2387271844 created "2016-06-24" @default.
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- W2387271844 date "2000-01-01" @default.
- W2387271844 modified "2023-09-23" @default.
- W2387271844 title "Efficacy and safety of cerivastatin in treatment of primary hypercholesterolaemia" @default.
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