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- W2387279655 abstract "Objective:To investigate the expression and secretion of int er leukin-6(IL-6)by lamina propria mononuclear cells(LPMC)in the patient with ulc erative colitis(UC).Methods:IL-6 was measured using an ELISA te chnique,and IL-6 mRNA was detected by RT-PCR in 32 patients with UC and 4 0 control subjects.In addition,the contribution of exogenous IL-17 and a nti-IL-17 monoclonal antibody(MoAb)to IL-6 production by LPMC was studied.Results:As compared to controls, serum concentrations of IL-6 from UC patients were higher,but with no statistic difference.However,the expression of IL-6 mRNA and secretion of IL-6 by the peripheral blood mononuclear cells in the UC patients were higher than that in the normal controls in the presence of stimuli(both P0.01).LPMC from the UC involved colons expressed large amo unt of IL-6 mRNA and spontaneously produced higher level of IL-6 protein c ompared with LPMC from the uninvolved colons did,which significantly correlated with the serum CRP levels and ESR,respectively.Addition of exogenous IL-17 to LPMC from involved colons resulted in increase of IL-6 production in vitro.Howe ver,addition of anti-IL-17 MoAb resulted in decrease of IL-6 secretion signif icantly.Conclusion:LPMC from UC involved colons expressed high l evels of IL-6 mRNA and produced higher levels of IL-6 protein, which was corre lated with disease activity.IL-17 plays an important modulating role in the IL -6 secretion by LPMC." @default.
- W2387279655 created "2016-06-24" @default.
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- W2387279655 date "2001-01-01" @default.
- W2387279655 modified "2023-09-23" @default.
- W2387279655 title "Expression of interleukin-6 by lamina propria mononuclear cells in the patient with ulcerative colitis" @default.
- W2387279655 hasPublicationYear "2001" @default.
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