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- W2387282007 abstract "Objective To explore the best dosage of streptozocin (STZ) what was used to induce rat model of Type 2 diabetes mellitus (T2DM). Methods Sixty 4 weeks old male Sprague Dawley (SD) rats were fed with high fatty and high sugar diet for 4 weeks, then STZ (30 mg/kg?40 mg/kg?50 mg/kg) was injected intraperitoneally to make rat model of T2DM, each phase avoirdupois, appetite and the amount of urine and drinking of rat model were tested, in unison, the fasting blood glucose level (FBG), serum insulin level (FINS) and blood lipid were also detected, the data was used to evaluate the stability of the rat model of T2DM. Results The 40 mg/kg group has the highest making model success rate of over 73.3%, all the succeed model rat has insulin resistance, hyperglycemia, blood lipid disorder and blood insulin increased which were the typical characteristic of T2DM, and duration of high blood glucose was the longest and the most stabile too. Only 40% of the 30 mg/kg group has succeed, beside the blood glucose level has get right until the end of experimental. The successful rat models of the 50 mg/kg group were inclined to type 1 diabetes mellitus. Conclusion Associate with high fatty and high sugar diet feeding shortly, the best dosage of STZ which was used to induce rat model of T2DM is 40 mg/kg." @default.
- W2387282007 created "2016-06-24" @default.
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- W2387282007 date "2007-01-01" @default.
- W2387282007 modified "2023-09-23" @default.
- W2387282007 title "Study on the Best Dosage of Streptozocin in Inducing Rat Model of Type 2 Diabetes Mellitus" @default.
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