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- W2387282685 abstract "Objective: To prepare small size niosome drug delivery system for 5-fluorouracil,characterize its physicochemical properties and study its antitumor effects in vitro and in vivo. Methods: The niosomes were prepared by solvent injection method,and characterized by investigation of their physical properties,such as morphology,particle size,encapsulation efficiency and in vitro release behavior. Antitumor effects were evaluated by cell toxicity test against two kinds of tumor cells in vitro and by tumor suppression test in tumor-bearing mice in vivo. Results: The average diameter of the prepared spherical niosomes was( 240. 4 ± 10. 1) nm with Zeta potential of-68. 37 m V,FALT of 1. 83 nm and encapsulation rate of 32. 76%. The release profile in vitro could be described by Weibull distribution equation,and showed an obvious sustained release feature in simulated normal body fluid as indicated by a release t1 /2of 3. 47 times as long as that of the free drug. Cell toxicity test demonstrated that the niosomes had significant inhibitory effect against tumor cell growth when compared with the free drug,with IC50 decreased to 9. 1% ~ 18. 4% of the free drug( P 0. 01). The niosomes significantly inhibited tumor growth in the tumor-bearing mice. The tumor growth inhibition rate increased to 48. 45% from 19. 58% for the free drug of the same concentration. Conclusion: The prepared fluorouracil-loaded niosomes have desirable physical properties and significant drug sustained release feature and demonstrated obvious antitumor effects in the cell tests and animaltests,which provides a promising candidate of novel microparticul antitumor drug delivery system." @default.
- W2387282685 created "2016-06-24" @default.
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- W2387282685 date "2015-01-01" @default.
- W2387282685 modified "2023-09-23" @default.
- W2387282685 title "Preparation,characterization and antitumor effects of fluorouracil-loaded small size stealth niosomes" @default.
- W2387282685 hasPublicationYear "2015" @default.
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