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- W2387289625 abstract "Objective To investigate the cytotoxicity and DNA damage induced by diethylnirtosamine(DENA) in human hepatic stem cell,so as to provide theoretical basis for evaluating its genetic toxicity.Methods Human hepatic stem cells were exposed to six doses of DENA(0,450,900,1350,1800,2250 μg/ml).Cell survival and DNA damage were evaluated by methyl thiazolyl tetrazolium(MTT) assay and single cell gel electrophoresis(SCGE) respectively.Hoechst 33258 staining was used to detect the apoptosis of fetal hepatic stem cells.Results The survival rate of fetal hepatic stem cell was significantly lower than that of control group(P0.05) at the dose of 900,1350,and 1800 μg/ml after 48 h treatment.When hepatic stem cells were exposed to DENA for 24 h,cellular apoptosis occurred with karyopyknosis and deep staining.Break in DNA strands was found at 900,1350 μg/ml of DENA,the content of DNA in tail((18.44±4.99)%,(17.33±3.29)% respectively) was higher than that of the control((0.015±0.004)%)(P0.01),while the comet length was decreased at higher doses(1800,2250 μg/ml)(P0.01).Conclusion DENA could induce direct DNA damage of human hepatic stem cells in vitro,so it might have some potential genetic toxicity." @default.
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- W2387289625 date "2012-01-01" @default.
- W2387289625 modified "2023-09-24" @default.
- W2387289625 title "THE CYTOTOXICITY EFFECT OF DIETHYLNITROSAMINE IN HUMAN HEPATIC STEM CELLS" @default.
- W2387289625 hasPublicationYear "2012" @default.
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