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- W2387291271 abstract "Objective To investigate the value of screening preliminarily diagnosed leukemia according to the warning informations of suspicious morphology of the international blood cell review rules by Beckman Coulter LH755 hematology analyzer,and to provide the reference for re-examination of blood cells.Methods 1 984 cases were classified into non-leukemia group(1 832 cases),preliminarily diagnosed leukemia group(73 cases) and further consultation group(79 cases).All specimens were detected for leucocyte differentiation and cell morphology observation by instrumental analysis and manual examination.According to the international blood cell review rules,the relative international blood cell review rules were evaluated in non-leukemia and preliminarily diagnosed leukemia groups.The changes of suspicious warning between leukemia and non-leukemia groups before and after treatment were observed.Using receiver operating characteristic(ROC) curve,the value of diagnosing leukemia preliminarily was observed.Results A total of 724 preliminarily diagnosed leukemia cases involved suspicious warning rules,including 655 cases of non-leukemia group,69 cases of leukemia group and 46 myeloid leukemia patients.The microscopy results were positive.The terms of 34(left alarm) and 37(blast cell alarm)were more sensitive and positively predictive.The terms of 30 [platelet(PLT) aggregation alarm],31(PLT alarm) and 35 [non-typical and(or) variation Lym] had lower positive predictive value.The false negative cases were detected in 28 cases.There were 8 cases detected blast cells,and these samples were all from the leukemia patients after treatment(28.57%,8/28).According to the ROC curve,the term of 37(blast cell alarm) had the highest value(AUC = 0.821)to the preliminarily diagnosed leukemia patients,followed by the 34(left alarm),32(IG alarm),26(white blood result unreliability) and 35 [non-typical and(or) variation Lym].The terms of 30(PLT aggregation alarm) and 31(PLT alarm) had low value.Conclusions The international blood cell suspicious warning review rules has an important value in diagnosing leukemia preliminarily.The cell morphology after treatment is more varied and complex in leukemia patients,and the instruments can not directly provide the accurate information of blood cell change,which is needed to be further verified by manual microscopy.The case involving term 37(blast cell alarm) needs microscopy,and the case involving term 26(white blood result unreliability),32(IG alarm),34(left alarm) and 35 [non-typical and(or) variation Lym],also should be paid attention to avoid misdiagnosis." @default.
- W2387291271 created "2016-06-24" @default.
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- W2387291271 date "2011-01-01" @default.
- W2387291271 modified "2023-09-23" @default.
- W2387291271 title "Investigation of screening preliminary diagnosed leukemia according to the warning informations of suspicious morphology of the international blood cell review rules" @default.
- W2387291271 hasPublicationYear "2011" @default.
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