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- W2387315033 abstract "Objective To investigate the prevalence of vancomycin-resistance gene and five virulence determinants in Enterococcus of clinical isolates,and to explore the possible correlations between vancomycinresistance and virulence determinants. Methods One hundred and twenty-two isolates were collected to determine their antimicrobial susceptibility to vancomycin and teicoplanin by E-test. The vanA, vanB and specie specific genes for Entercoccus faecalis and Entercoccus faecium were detected using multiplex PCR assay. The occurrence of the esp, hyl, gelE, asa1 and cylA were also detected by multiplex PCR. Results Among the 122 isolates, VRE accounted for 76 including 69 Entercoccus faecium and 7 Entercoccus faecalis, VSE accounted for 46 including 28 Entercoccus faecium and 18 Entercoccus faecalis. All VRE displayed their vancomycin-resistant phenotypes and genotypes, consistently with vanA gene positive. Entercoccus faecalis showed higher prevalence of virulence traits than Entercoccus faecium, which only carried esp and hyl. The presence of esp in vancomycin-resistant Entercoccus faecium was significantly higher than that of the sensitive ones. Conclusion Drug resistance of Enterococcus was a serious problem in our hospital. Esp was the most widely distributed gene among five virulence related genes, it had a strong relationship with vancomycin resistance. Monitoring VRE along with their virulence traits will provide valuable information for preventing and control the prevalence and spread of multidrug-resistant Enterococcus species." @default.
- W2387315033 created "2016-06-24" @default.
- W2387315033 creator A5023069042 @default.
- W2387315033 date "2014-01-01" @default.
- W2387315033 modified "2023-09-25" @default.
- W2387315033 title "Drug resistance and virulence determinants in vancomycin-resistant Enterococci" @default.
- W2387315033 hasPublicationYear "2014" @default.
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