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- W2387319382 abstract "Objective To study the protein expressions of Fas-associated with death domain protein(FADD) and caspase-8,and the effects of edaravone on them.Methods The rats were subjected to the middle cerebral artery occlusion for two hours,then killed at different time points after reperfusion.The protein expressions of FADD and caspase-8 were detected by immunohisto-chemistry.Results The protein expressions of FADD and caspase-8 were markedly increased at 3 h after reperfusion in the penumbra of rat cortex,and peaked at 12 h((P0.01),) then declined quickly at 24 h.Edaravone treatment could significantly downregulate the FADD and caspase-8 protein expressions after 3 h of reperfusion(P0.01,P0.05).Conclusions FADD and caspase-8 may play important roles in the cerebral ischemia and reperfusion injury.Edaravone could protect neurons from ischemic damage by decrease the expression levels of FADD and caspase-8." @default.
- W2387319382 created "2016-06-24" @default.
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- W2387319382 date "2007-01-01" @default.
- W2387319382 modified "2023-09-23" @default.
- W2387319382 title "Effect of Edaravone on FADD and caspase-8 Protein Expression Following Focal Cerebral Ischemia/Reperfusion" @default.
- W2387319382 hasPublicationYear "2007" @default.
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