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- W2387346304 abstract "Objective To explore the subacute toxicity of beta-cypermethrin(β-CP)by subacute inhalation in SD rats,thereby provide the evidences for determinating its maximum ineffective concentration and target.Methods SD rats were randomly divided into 5 groups,they were control group,solvent control group and 3 exposed groups(there were 6 female rats and 6 male rats for each group).The exposed dose of β-CP for these groups were 0,0,3.36,16.61,111.05 mg/m3,respectively;4 hours per day for 28 days.At the end of experiment,the rats were killed,the routine and biochemical detection,the body-weight and organ coefficient were all measured.Results In the high exposure group,growth of body weight was significantly inhibited,brain weight/body weight ratio was risen;axonal swelling and mild demyelination in sciatic nerve were observed in some rats;in female rats,lymphocyte percentages in blood decreased,MCV,MCH and adrenal gland to body weight ratio were increased;in male rats,the kidney,testis and epididymis weights to body weight ratios were all increased;while MCHC and total amounts of sperm were decreased.In both medium and high exposure groups,BUN levels of male rats were increased,sperm vitalities were decreased.Conclusions The results suggested that the maximum ineffective concentration of β-CP in SD rats was 3.36 mg/m3(4 h/d),and there were some neurotoxicity and reproductive toxicity at the concentration of 111.05 mg/m3(4 h/d)." @default.
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- W2387346304 date "2009-01-01" @default.
- W2387346304 modified "2023-09-24" @default.
- W2387346304 title "Study on the subacute inhalation toxicity of beta-cypermethrin in SD rats" @default.
- W2387346304 hasPublicationYear "2009" @default.
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