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- W2387346435 abstract "Aim:To investigate the influence of 8-Br-cAMP on the telomerase activity and P53 expression in the human lung adenocarcinoma cell line(A549).Methods:The human 1ung adenocarcinoma cell line(A549)was treated with 8-Br-cAMP (20 μmol/L,60 μmol/L),and the human lung adenocarcinoma cell untreated was taken as sham control. P53 expression and the telomerase activity were detected by immunohistochemisty and PCR-ELISA method in the course of differentiation of A549 cells.Results:Both P53 expression and the telomerase activity were signficantly decreased in the A549 cell line treated with 8-Br-cAMP.Conclusion:8-Br-cAMP could inhibit the telomerase activity and the P53 expression of A549 cells." @default.
- W2387346435 created "2016-06-24" @default.
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- W2387346435 date "2002-01-01" @default.
- W2387346435 modified "2023-09-23" @default.
- W2387346435 title "Influences of 8-Br-cAMP on the telomerase activity and P53 expression in the human lung adenocarcinoma cell A549 line" @default.
- W2387346435 hasPublicationYear "2002" @default.
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