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- W2387348652 abstract "AIM: To observe the expression of ATP-sensitive potassium(KATP) channel mRNA in mesenteric artery smooth muscle of rats with estrogen administration,and to evaluate the role of KATP channel in the effects of estrogen on the reactivity of mesenteric artery in rats.METHODS: Forty-eight female Sprague-Dawley rats,weighing(100±10) g,were randomly divided into 3 groups: sham operation(sham) group,ovariectomy(Ovx) group and ovariectomy with estrogen administration(Ovx+E) group.The mRNA expression of KATP subunits in mesenteric artery smooth muscle was detected by quantitative real-time PCR.Artery reactivity in the rats was observed by norepinephrine-induced pressor response.RESULTS: Compared with sham group,the mRNA expression of Kir6.1 and SUR2B was significantly decreased in Ovx group(P0.05),but increased in Ovx+E group(P0.05).Compared with sham group and Ovx+E group,the pressor response induced by norepinephrine in the rats were enhanced in Ovx group(P0.05).No significant difference between sham group and Ovx+E group was observed.After administered with glibenclamide(a KATP channel blocker),the pressor response induced by norepinephrine was enhanced in sham group and Ovx +E group,and no changes in Ovx group.Meanwhile,no difference among the 3 groups was found.CONCLUSION: Estrogen up-regulates the expression of KATP channel subunits,which may be involved in estrogen-reduced pressor response to norepinephrine." @default.
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- W2387348652 date "2012-01-01" @default.
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- W2387348652 title "Estrogen affects reactivity of rat mesenteric artery through ATP-sensitive potassium channel" @default.
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