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- W2387359369 abstract "Objective To establish a HPLC method for determination of vancomycin in serum and using the method for clinical monitoring the levels of vancomycin of patients with pulmonary infection.Methods HPLC analysis was performed using a Eclipse XDB C18 column(4.6 mm × 250 mm,5 μm).The mobile phase was KH2PO4(25 mmoL.L-1) : methanol(86 ∶ 14).The flow-rate was 1.0 mL.min-1 and the detection wavelength was 236 nm.The injection volume was 20 μL and the temperature of column was about 40 ℃.Results The concentration range of vancomycin was 5-100 mg.L-1 while the calibration curve showed good linearity(r = 0.999 6),and the minimum limit o f quantitation was 5.0 mg.L-1.The coefficient of methods recovery were 94.87 %.There lative standard deviations(RSD) of intra-day and inter-day were 6.06 % and 6.27 %,respectively.More over,the concent ration of vancomycin was lower than 10 mg.L-1 in 26.67 % of those 15 patients with pulmonary infection.Conclusion The method is simple,sensitive,rapid and highly reproducible,and it could be used for detecting the concentration of vancomycin in for pulmonary infection patients.The concentration of vancomycin has a large fluctuation in pulmonary infection and their suitable individual dosage regimen need to be administrated through therapeutic drug monitoring." @default.
- W2387359369 created "2016-06-24" @default.
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- W2387359369 date "2013-01-01" @default.
- W2387359369 modified "2023-09-25" @default.
- W2387359369 title "Monitoring of vancomycin serum concentration of patients with pulmonary infection" @default.
- W2387359369 hasPublicationYear "2013" @default.
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