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- W2387363424 abstract "Homophenylalanine is an unnatural amino acid which could be used in the synthesis of angiotensin converting enzyme inhibitors and other pharmaceuticals.It has been synthesized via condensation of acetophenone with diethyl oxalate,amination with NH4OAc,and reduction with hydrogen catalyzed by Pd/C.The optimum conditions were as follows:(1) condensation reaction by adding fresh NaOEt to the mixture of acetophenone and diethyl oxalate with the molar ratio of acetophenone to diethyl oxalate 1∶1.5;(2) amination reaction by mechanochemically grinding with NH4OAc;(3) reduction reaction by Pd/C catalyzed hydrogenation in autoclave at 90 ℃ under 5 MPa pressure to afford the target product.Under the optimal conditions,the overall yield of homophenylalanine is 87%.The target compound and key intermediate were characterized by nuclear magnetic resonance(NMR).The advantages of the above synthetic process are cheap raw materials,high overall yield and green procedure." @default.
- W2387363424 created "2016-06-24" @default.
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- W2387363424 date "2011-01-01" @default.
- W2387363424 modified "2023-09-23" @default.
- W2387363424 title "Study on a new process for the synthesis of homophenylalanine" @default.
- W2387363424 hasPublicationYear "2011" @default.
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