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- W2387366823 abstract "Objective To investigate the anti-tumor effect of atrial natriuretic peptide(ANP) and its role in tumor angiogenesis.MethodsANP was infused into tumor-bearing mice by micro pump,then tumor size was measured and tumor angiogenesis was analysed by HE staining.The human umbilical vein endothelial cells(HUVEC) were placed in wells containing growth factor-reduced Matrigel in the presence or Absence of vascular endothelial growth factor(VEGF165) and ANP.Endothelial tube formation was observed.ResultsANP inhibited growth and angiogenesis of melanoma and mastocytoma in the mice(P0.01,P0.001).ANP inhibited VEGF165-induced tube formation on Matrigel(P0.001).ConclusionANP might have the potential clinical usefulness,as an endogenous angiogenic inhibitor,in inhibiting the growth and angiogenesis of tumor." @default.
- W2387366823 created "2016-06-24" @default.
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- W2387366823 date "2008-01-01" @default.
- W2387366823 modified "2023-09-23" @default.
- W2387366823 title "Atrial natriuretic peptide inhibits growth and angiogenesis of tumor in mice" @default.
- W2387366823 hasPublicationYear "2008" @default.
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