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- W2387391210 abstract "Objective To screen the best extraction process of active fractions from Xiaoyaosan.Methods A series of similar extraction processes with the original extraction process were designed by changing the solvent and process.The commonly used mouse tail suspension test(TST) model was selected to investigate the antidepressant effect of extracts.Furthermore,HPLC was applied to establish the fingerprints of the extracts possessing significant efficacy.The fingerprints were evaluated to screen the optimum extraction method of active fractions.Results The locomotor activity of mice in open field test(OFT) was not affected by the medicine treatment.The effect of extracts from the process 0(original extraction process) in the mouse TST model was the closest to the positive drug.The process 3 and process 5 were easy to conduct and the effects were similar to that of process 0.In addition,the chemical compositions of extracts from process 0 and process 5 were consistent.Conclusion The process 5,collected by ethanol and extracted by petroleum ether after mixed with bergmeal,is the optimum extraction method for active fractions from Xiaoyaosan instead of the original extraction process." @default.
- W2387391210 created "2016-06-24" @default.
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- W2387391210 date "2012-01-01" @default.
- W2387391210 modified "2023-09-26" @default.
- W2387391210 title "Study on extraction process of active fractions from Xiaoyaosan" @default.
- W2387391210 hasPublicationYear "2012" @default.
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