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- W2387391566 abstract "Objective To study the approach to reverse resistance of Mer+ glioma to CENUs.Methods The influence of pre exposure to O 6 BG on the resistance of human glioma cells and xenografts transplanted in nude mice to BCNU were observed. Results 10 micro M of O 6 BG could obviously deplete MGMT activity of Mer+ glioma cell and the complete consumption was observed when more than 50 micro M of O 6 BG was used. 2 2 times of elevation of sensitivity in Mer+ glioma cell line T98G to BCNU was observed after 2 hours of pretreatment with 50 micro M of O 6 BG of which the cytotoxicity was considerably slight. And the group treated with O 6 BG plus BCNU produced a more significant tumor growth delay, 34 16days longer than the control, also 18 days longer than the guoup treated with BCNU alone(P0 01). The O 6 BG+BCNU group also produced a temporary tumor regression, whereas the group treated with BCNU alone produced no tumor regression. Conclusions By delepting MGMT activity, O 6 BG could reverse BCNU resistance of the tumors with a high MGMT activity to BCNU and further enhance the effect of BCNU on Mer+ brain tumors. This study suggested that O 6 BG may be a useful adjuvant to nitrosourea therapy." @default.
- W2387391566 created "2016-06-24" @default.
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- W2387391566 date "2002-01-01" @default.
- W2387391566 modified "2023-09-25" @default.
- W2387391566 title "Study on reversing resistance of human gliomas to BCNU" @default.
- W2387391566 hasPublicationYear "2002" @default.
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