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- W2387392099 abstract "Objective To investigate effects of Naoyikang on improving learning and memory ability and inflammation reaction of Alzheimers′ disease (AD) model rats. Methods AD model rats were established by the injection of Aβ1~40 into the right hippocampus. After intragastrically administrated with different solution for 28 days,learning and memory abilities of rats were tested by Y-maze. The levels of TNF-α and IL-6 in AD rats′ hippocampus were detected by immunohistochemistry. The levels of IL-1β、TGF-β1 in cortex were measured by ELISA. Results Naoyikang could improve the learning and memory abilities of AD rats,descend significantly the concentration of IL-1β、IL-6 and TNF-α (P0.01),and increase the expression of TGF-β1(P0.01).Conclusions Naoyikang can improve the learning and memory abilities of AD rats,and effectively control the inflammation reaction by decreasing the content of IL-1β,IL-6 and TNF-α and increasing the expression of TGF-β1." @default.
- W2387392099 created "2016-06-24" @default.
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- W2387392099 date "2010-01-01" @default.
- W2387392099 modified "2023-09-25" @default.
- W2387392099 title "Effects of Naoyikang on improving learning and memory ability and inflammation reaction of Alzheimer′s Disease model rats" @default.
- W2387392099 hasPublicationYear "2010" @default.
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