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- W2387439263 abstract "To investigate the effects of bromibenzyltetrahydraberberine on delayed rectifier potassium current and inward rectifier potassium current and L-type calcium current in isolated single guinea pig ventricular myocyte. Single ventricular cell was obtained from healthy guinea pig hearts using enzymatic dissociation technique. The whole cell patch clamp method was used to record the delayed rectifier potassium current(I K), the inward rectifier potassium current(I K1), and the L-type calcium current (I Ca-L). Results: Bromibenzyltetrahydraberberine has dose-dependent blocking effects on I K.ID 50 is 56μmol/L. It has no change on I-V shape of I K. It has no obvious effect on I K1. Bromibenzyltetrahydraberberine has dose-dependant blocking effect on I Ca-L .ID 50 is 65μmol/L. The inhibition of bromibenzyltetrahydraberberine on I Ca-L was dependent of the holding potential (HP).75μmol/L bromibenzyltetrahydraberberine inhibited I Ca-L by 0.4922±0.021 at HP=-40 mV, and 0.6377±0.0366 at HP=-80 mV. Conclusion: Bromibenzyltetrahydraberberine can decrease delayed rectifier potassium current and L-type calcium current in single guinea pig ventricular myocyte. It is a muti-ion blocking antirarrhythmia agent." @default.
- W2387439263 created "2016-06-24" @default.
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- W2387439263 date "2004-01-01" @default.
- W2387439263 modified "2023-09-24" @default.
- W2387439263 title "Effects of Bromibenzyltetrahydraberberine on Ion Channels in Guinea Pig Ventricular Myocytes" @default.
- W2387439263 hasPublicationYear "2004" @default.
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