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- W2387450592 abstract "Objective Our study aims to investigate impacts of double-stranded RNA(dsRNA) of different lengths on stress granule(SG) formation and to explore the underlying mechanism. Methods A549 cells were transfected with dsRNA of different lengths, including HMW(height molecular weight, 1.5-8 kb), LMW(light molecular weight, 0.2-1 kb), and small dsRNA(19 bp). Immunofluorescence staining microscopy was performed to detect the SG formation. Activation of protein kinase R(PKR) and eukaryotic initiate factor 2α(eIF2α) were determined by Western blot using the antibodies specific detecting their phosphorylated forms. Results SG was induced in A549 cells transfected with HMW and LMW dsRNA, but not with small dsRNA. Phosphorylation of PKR and eIF2α were detected in cells transfected with HMW and LMW dsRNA, but not with small dsRNA. Conclusion These data suggest that minimizing dsRNA length might be a strategy for virus to keep PKR inactive and to escape SG formation." @default.
- W2387450592 created "2016-06-24" @default.
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- W2387450592 date "2014-01-01" @default.
- W2387450592 modified "2023-09-26" @default.
- W2387450592 title "Study on stress granule formation induced by dsRNA" @default.
- W2387450592 hasPublicationYear "2014" @default.
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