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- W2387455103 abstract "Objective To explore the relationship between serum fibrinolytic activity and triglyceride(TG) in patients with acute coronary syndrome(ACS) and clinical correlation between these markers and ACS. Methods The activity of plasminogen activator inhibitor 1(PAI-1) and tissue plasminogen activator(tPA)was simultaneously measured in 88 patients with ACS 54 with acute myocardial infarction (AMI),34 with unstable angina (UA),and 16 normal subjects were as a control. These patients were divided into 4 groups:AMI with hypertryceridemia(HTG),AMI with normal serum TG, UA with HTG,and UA with serum normal TG.The correlation between serum TG and PAI-1 and tPA activity was analysed.Cardiovascular events were observed in patients with ACS in first 6 weeks. Results ①PAI-1 activity was higher in patients with ACS than in control group(P0.001),but tPA activity was lower than in control group.In particular, the fibrinolytic activity of serum high TG in patients with ACS was sigificantly lower than those with normal TG (P0.001); TG was positively correlated with PAI-1 activity (r=-0.43,P0.001).②Patients with event had significantly higher PAI-1 activity than those without (P0.001),and had significantly lower tPA activity than those without (P=0.003).In particular,the ratio of early cardiovascular event in patients with high PAI-1 activity andTG level was higher than that of patients in other groups (χ~2=14.695,P0.001) . Conclution in ACS patients fibrinolytic activity is decreased,TG may play an important role in the pathogenesis of ACS. Elevated PAI-1 activity can predict the extent of coronary artery lesion.Higher plasma PAI-1 with higher TG concentration can indicate the prognosis of patients with ACS." @default.
- W2387455103 created "2016-06-24" @default.
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- W2387455103 date "2006-01-01" @default.
- W2387455103 modified "2023-09-25" @default.
- W2387455103 title "Correlation of serum fibrinolytic activity and triglyceride with clinical features in patients with acute coronary syndrome" @default.
- W2387455103 hasPublicationYear "2006" @default.
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