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- W2387457202 abstract "Objective To investigate the clinical significance of airway hyperresponsiveness and eosinophil(Eos)percentage and level of eosinophil cationic protein(ECP)in induced sputum in patients with asthma during their remission period.Methods Seventy-six patients with asthma during their remission period were selected.Bronchial challenge test was performed and the percentage of Eos and level of ECP in induced sputum were measured by Wrights' stain and Immuno-CAP System,respectively.Thirty patients with asthma during their exacerbation period and twenty healthy subjects were selected as controls.Results In seventy-six patients with asthma during their remission period,sixty-five(85.5%)showed positive bronchial challenge test and eleven(14.5%)patients showed negative bronchial challenge test.The percentage of Eos and level of ECP in induced sputum in patients with asthma during their remission period were 0.071±0.032 and 131.5 μg/L respectively;those in asthma group during their exacerbation period and healthy group were 0.198±0.103 vs 0.013±0.007 and 355.3 μg/L vs 48.0 μg/L,respectively.There was significant difference in the percentage of Eos and level of ECP in induced sputum between three groups(P0.01).The percentage of Eos and level of ECP in induced sputum in asthmatic patients with positive bronchial challenge test and asthmatic patients with negative bronchial challenge test during their remission period were 0.198±0.031 vs 0.026±0.012 and 143.7 μg/L vs 41.3 μg/L,respectively.There was significant difference in the percentage of Eos and level of ECP in induced sputum between two groups(P0.01).Conclusion Airway hyperresponsiveness and persistent airway inflammation still exist in the asthmatic patients during their remission period.It may be helpful to guide treatment during the remission period to determine airway hyperresponsiveness and inflammatory markers in induced sputum." @default.
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- W2387457202 date "2007-01-01" @default.
- W2387457202 modified "2023-09-24" @default.
- W2387457202 title "Clinical significance of airway hyperresponsiveness and inflammatory markers in induced sputum in patients with asthma during their remission period" @default.
- W2387457202 hasPublicationYear "2007" @default.
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