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- W2387459275 abstract "Objective To investigate the effect of experimental varicocele on the prostatic oxidative stress in rats. Methods Twenty four male wistar rats were created into varicocele models by partial ligation of the left renal vein as the experimental group, with 18 sham-operated rats as the control group. Prostates were harvested at 4, 8 and 16 weeks after surgery. The levels of superoxide dismutase (SOD), glutathione peroxidase (GPx) and malodialdehyde (MDA) were measured by biochemical method. The mRNA expression of CuZn-SOD and GPx were detected by RT-PCP. Results At 4 weeks after surgery, there were no significant differences of the SOD, GPx, MDA and GPx mRNA levels between the two groups (P0.05), while the expression of CuZn-SOD mRNAwas significantly higher in the experimental group(0.366±0.085) than in the control group(0.221±0.043) (P0.05). At 8 weeks after surgery, the levels of SOD and GPx were significantly lower, while the levels of MDA, CuZn-SOD mRNA and GPx mRNA were significantly higher in the experimental group than in the control group (P0.05). At 16 weeks after surgery, the levels of SOD and GPx were significantly lower, and the MDA level was significantly higher in the experimental group(4.26±1.61)than in the control group(2.35±0.85) (P0.05). While there were no significant difference of the CuZn-SOD mRNA and GPx mRNA levels between the two groups (P0.05). Conclusions An experimental varicocele can lead to increased reactive oxygen species and decreased antioxidant enzymes levels in prostate, which may be one of the important factors of male infertility induced by varicocele." @default.
- W2387459275 created "2016-06-24" @default.
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- W2387459275 date "2006-01-01" @default.
- W2387459275 modified "2023-09-26" @default.
- W2387459275 title "Effect of experimental varicocele on the prostatic oxidative stress in rats" @default.
- W2387459275 hasPublicationYear "2006" @default.
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