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- W2387460216 abstract "Objective To investigate the radiosensitizing effect and the mechanism of action of tetrandrine(Tet) in human breast cancer MCF 7/ADR and MCF 7 cells. Methods The effect of Tet on the cytotoxicity of γ-ray was determined by clonogenic assay. Cell cycle arrest induced by γ irradiation was studied in the two cell lines by using flow cytometry, Western blotting was preformed to indicate the changes of Cyclin B1 and Cdc2 protein levels. Results Tet sensitized MCF 7/ADR cell line with mutant p53 to γ-ray by clonogenic assay. Flow cytometry assay showed that exposure of MCF 7/ADR cells to γ-ray caused cells arrest in G_2 phase. The SER of Tet was 1.51 in MCF 7/Adr cells. However, in MCF 7 cell line with wild p53, the SER of Tet was 1.10, the numbers of arrest G_2 phase cells were less than those in MCF 7/ADR cell line. It indicated that the sensitizing effect was lower than that in the p53 mutant cancer cells. The addition of Tet after irradiation resulted in a dose-dependent reduction of G_2 phase arrest induced by γ-ray. Furthermore, the results showed that Tet blocked decrease of Cyclin B1 and Cdc2 expression induced by γ-ray, while mitotic index measurement indicated that γ-ray-irradiated cells treated with Tet entered mitosis. Conclusion Tet is a potent G_2_ checkpoint abrogator and markedly enhances the cytotoxicity of γ irradiation in the p53 mutant cancer cells." @default.
- W2387460216 created "2016-06-24" @default.
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- W2387460216 date "2005-01-01" @default.
- W2387460216 modified "2023-09-25" @default.
- W2387460216 title "Study of potentiation of radiosensitivity by tetrandrine and its mechanism" @default.
- W2387460216 hasPublicationYear "2005" @default.
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