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W2387463315 abstract "The self-renewal and directed differentiation of hematopoietic stem cell is regulated by a variety of hematopoietic growth factors,such as interleukin(IL)-3,granulocyte-macrophage colony stimulating factor(GM-CSF),IL-5,which played important rolees in the regulation.These cytokines binding with their receptors on the target cells to transduce survival signals via activating the downstream signals.Studies have shown that the abnormal expression of IL-3,GM-CSF and their receptors and the mutations and dysfunction of the transcription factors in human acute myeloid leukemia.Therefore,researchists hypothesized that the blocked differentiation of acute myeloid leukemia may be related to the abnormal expression of IL-3R system and transcription factors." @default.
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W2387463315 date "2011-01-01" @default.
W2387463315 modified "2023-09-24" @default.
W2387463315 title "Progress of the Relationship between Acute Myeloid Leukemia and Interleukin-3 Receptor System,the Transcription Factors" @default.
W2387463315 hasPublicationYear "2011" @default.
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