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- W2387463803 abstract "Objective To detect the phosphatidylinositol 3-kinase activity in adipose tissue of diabetes mellitus(GDM) patients,thus to explore the molecular mechanisms of insulin resistance of GDM.Methods Samples from patients with GDM(GDM group,n=35),and healthy pregnant women(controls group,n=35) were collected.Fasting insulin(FIN) was measured by radioimmunoassay.Fasting plasma glucose(FPG) was determined by oxidase assay.PI-3 kinase activity was detected by immunoprecipitation,thin-layer chromatography and gamma scintillation counting.The results were analyzed statistically.Results The levels of serum FPG[(7.85±3.51) mmol/L],FIN [(25.17±3.76) mU/L] and HOMA-IR(1.75±0.12) in GDM group were significantly higher than those in control group(P0.01);PI-3 kinase activity(85.75%) was significantly decreased in GDM group compared with control group(P0.01)and negatively correlated with HOMA-IR(r=-0.74,P0.01).Conclusions PI-3 kinase may affect the insulin signaling pathway,and takes part in the insulin resistance of gestational diabetes mellitus." @default.
- W2387463803 created "2016-06-24" @default.
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- W2387463803 date "2010-01-01" @default.
- W2387463803 modified "2023-09-24" @default.
- W2387463803 title "Analysis of phosphatidylinositol 3-kinase activity in the adipose tissue of gestational diabetes mellitus patients" @default.
- W2387463803 hasPublicationYear "2010" @default.
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