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- W2387479050 abstract "Objective To investigate the effect of ginkgo biloba extract (ginaton) to retinal vascular form and density in oxygen-induced retinopathy. Methods Forty-eight newborn Sprague Dawley (SD) rats were randomly divided into air group, oxygen group and treatment group (ginaton, intraperitoneal injection of 50 mg/kg). Newborn rat models of ROP were established by repeated fluctation oxygen. The status of retinal vasculature were observed on 14th day and 19th day. Eight newborn rats were selected randomly from each group respectively. The retinas were dissected and stained by using a histochemical method for detecting adenosine diphosphatase (ADPase). HE staining on the other eye of the rat was used for counting the number of nuclei extending from retinal area into vitreous to identify extraretinal neovascularization. Results On 14th day and 19th day, in oxygen group the main vascular become thinner, and the distribution of vascular become diorder. However, there was no significant change in the treatment group. On 19th day, the numbers of nuclei extending from retinal area into vitreons in oxygen group (34.6±5.3) were significantly higher compared to the air group (5.0±2.1)(t=-44.120, P0.001), but the numbers of nuclei in treatment group (12.6±3.4) were less compared to oxygen group (t=-31.312, P0.001). Conclusion Fluctation in oxygen can successfully induce ROP model. Ginaton can exhibit protective effects on oxygen-induced retinopathy (OIR) rat model." @default.
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- W2387479050 date "2012-01-01" @default.
- W2387479050 modified "2023-09-26" @default.
- W2387479050 title "Effect of ginkgo biloba extract to retinal vascular form and density in oxygen-induced retinopathy" @default.
- W2387479050 hasPublicationYear "2012" @default.
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