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- W2387486542 abstract "Objective:Systemly understanding th e update research progression of E-cadherin adhesion made in basis and clinics.M ethods:This review looks at the gene structure and interaction of the E-cadherin -catenin complex and the factors that appear to regulate E-cadherin expression.R esults:The E-cadherin-catenin complex plays a crucial role in epithelial cell-ce l l adhesion and in the maintenance of tissue architecture.Downregulation of the E -cadherin/catenin complex may occur in several ways amongst which are gene mutat ions,methylation of 5'CpG dinucleotides within the promotor region of E-cadherin ,tyrosine phosphorylation of beta-catenin,Perturbation in the expression or func tion of this complex results in loss of intercellular adhesion,with possible con sequent cell transformation and tumour progression.Conclusion 1:Recent developme nts show that the E-cadherin-catenin complex is more than a'sticky molecular com plex'.further studies may yield greater insight into the early molecular interac tions critical to the initiation and progression of tumours.This should aid the development of novel strategies for both prevention and treatment of cancer." @default.
- W2387486542 created "2016-06-24" @default.
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- W2387486542 date "2001-01-01" @default.
- W2387486542 modified "2023-09-25" @default.
- W2387486542 title "Progression of adhesion junction system mediated by E-cadherin" @default.
- W2387486542 hasPublicationYear "2001" @default.
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