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- W2387493664 abstract "OBJECTIVE:To summarize current studies on the relationship between nectin and cell adhesion,cell migration,and explore the value of nectin in cell motility,proliferation and metastasis.METHODS:A total of 362 English papers were searched with nectin and cell migration as key words in Medline and CNKI databases from 2000 to 2009.Twenty-three papers were selected according to the standards as follows: 1) the general characteristics of nectin;2) nectin mediating the cell-cell adhesion;3) the relationship between the nectin and cell migration,cell polarization;4)the relationship between the nectin and tumor genesis and development.RESULTS: Nectin is a newly discovered class of adhesion molecules,it can mediate the connections and the formation of tight junctions among epithelial cells and fibroblasts.Nectin can lead cells to lose their stability,enhance cells' proliferation activity and athletic ability.Nectin can promote the tendency to transformation,and it contributes to the occurrence and development of malignant tumors.Currently,the specific mechanisms that nectin promotes occurrence and development of tumor was not browed.CONCLUSIONS: Nectin can mediate the cell-cell connections,and promote cell movement,polarization and transfer,thus contributing to the occurrence of malignant tumors.The proliferation,metastasis and invasion capability of malignant cells have been greatly strengthened throuth the expression of nectin.Nectin provides a new scientific basis for human tumor diagnosis and treatment,but the specific mechanisms and methods should to be further studied." @default.
- W2387493664 created "2016-06-24" @default.
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- W2387493664 date "2010-01-01" @default.
- W2387493664 modified "2023-09-28" @default.
- W2387493664 title "Research advances of relationship between nectin and cell adhesion" @default.
- W2387493664 hasPublicationYear "2010" @default.
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