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- W2387494509 abstract "Objective To investigate the expression levels of IL-8 in plasma,and IL-8,its receptors( CXCR1 /CXCR2) and G protein-coupled receptor kinase 5( GRK5) in peripheral blood mononuclear cells( PBMC) from the patients with primary biliary cirrhosis( PBC) and their clinical significances. Methods The mRNA levels of IL-8,CXCR1,CXCR2 and GRK5 and the protein levels of CXCR1 and CXCR2 in PBMCs from 25 PBC patients and 25 health controls were detected by quantitative real time polymerase chain reaction( qRT-PCR) and Western blot,respectively. The levels of IL-8 in plasma and ALP and GGT in serum were determined by ELISA and continuous monitoring method,respectively. Then,the correlations between these markers were analyzed. Results Plasma IL-8 concentration in PBC patients [( 73. 43 ± 13. 24) pg / mL] was significantly higher than that in the controls [( 34. 76 ± 10. 12) pg /mL) ]( P 0. 01). Similarly,the mRNA levels [M( P25,P75) ]of IL-8 [2. 17( 0. 96,2. 84) vs 0. 99( 0. 48,1. 35) ],CXCR1 [1. 71( 0. 97,3. 26) vs 0. 99( 0. 39,1. 24) ],CXCR2 [1. 64( 0. 95,2. 56) vs 1. 06( 0. 56,1. 32) ]and GRK5 [1. 86( 1. 34, 2. 30) vs 0. 99( 0. 53,1. 28) ]in PBC patients were also significantly higher than those in the controls( P 0. 05). Western blot demonstrated that the protein levels of CXCR1 and CXCR2 also increased in PBC patients. In addition,the activities [M( P25,P75) ]of serum ALP [128. 0( 99. 5,164. 5) IU / mL vs 51. 0( 42. 3,62. 0) IU / mL] and GGT [85. 0( 43. 5,138. 0) IU / mL vs 14. 0( 12. 0, 16. 8) IU / mL]in PBC patients were significantly higher than those in the controls( P 0. 01). There was no any correlation between these markers except positive correlations between IL-8 and CXCR1( r = 0. 420,P 0. 05),between CXCR1 and CXCR2( r = 0. 441, P 0. 05),between CXCR2 and GRK5( r = 0. 515,P 0. 01),and between ALP and GGT( r = 0. 702,P 0. 01). Conclusion The expression levels of IL-8 and its receptors increased in PBC patients,suggesting that IL-8 and its receptors signal transduction process may play an important role in the pathogenesis of PBC,which provides a new direction for the immune intervention therapy of PBC. However,the increase of IL-8 and its receptors was not related to the severity of PBC." @default.
- W2387494509 created "2016-06-24" @default.
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- W2387494509 date "2014-01-01" @default.
- W2387494509 modified "2023-09-23" @default.
- W2387494509 title "Expressions and clinical significances of IL-8 and its receptors( CXCR1/2) in peripheral blood from the patients with primary biliary cirrhosis" @default.
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