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- W2387494880 abstract "Objective To investigate the relationship between HLA-DRB1*15 allele and the efficacy of adefovir dipivoxil in chronic hepatitis B for six months.Methods 94 chronic hepatitis B patients treated with adefovir dipivoxil were selected and divided into 52 cases of effective group and 42 cases of ineffective group.HLA-DRB1*15 was detected by using the polymerase chain reaction sequence specific primer(PCR-SSP),and the Frequencies of HLA-DRB1*15 were analyzed between the two groups.Results No significant difference was found in HLA-DRB1*15 frequency with hepatitis e antigen in chronic hepatitis B or in the same antiviral effect group.The frequency of HLA-DRB1*15 in effective group was significantly higher than that in ineffective group(χ2=5.050,P=0.025,OR=3.176,95%CI:1.127 ~8.951).Conclusion HLA-DRB1*15 allele in chronic hepatitis B or in the same antiviral effect group has no relationship distribution with hepatitis e antigen.HLA-DRB1*15 might be an effective treatment predictor marker of adefovir dipivoxil." @default.
- W2387494880 created "2016-06-24" @default.
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- W2387494880 date "2012-01-01" @default.
- W2387494880 modified "2023-09-27" @default.
- W2387494880 title "Correlation of HLA-DRB1*15 allele with short term antiviral effect of adefovir dipivoxil" @default.
- W2387494880 hasPublicationYear "2012" @default.
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