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- W2387496161 abstract "Objective To predict the epitopes of Mycobacterium tuberculosis Rv3407 protein. Methods The amino acid sequence of Rv3407 protein was analyzed using Protean in DNAStar and B cell and T cell epitopes were predicted using multiple parameters,including the secondary structure,hydrophilicity,antigenicity,surface probability,and flexibility. Results The Rv3407 protein has an extensive secondary structure and multiple regions with high antigenicity.There were a few potential B cell epitopes at or near amino acids 11-26,28-43,50-61,66-74,and 76-99.Theses epitopes had greater antigenicity,a beta turn,and a high level of hydrophilicity,surface probability,and flexibility.There were potential T cell epitopes at or near amino acids 2-12,22-26,34-37,40-44,56-60,75-79,and 86-93. Conclusion M.tuberculosis Rv3407 protein is an antigen with a dominant T-cell epitope.B cell epitopes also exist but are less prevalent than T cell epitopes.This prediction of epitopes has laid the foundation for the further study and use of this protein." @default.
- W2387496161 created "2016-06-24" @default.
- W2387496161 creator A5075456464 @default.
- W2387496161 date "2014-01-01" @default.
- W2387496161 modified "2023-09-23" @default.
- W2387496161 title "Prediction of epitopes of Mycobacterium tuberculosis Rv3407 protein" @default.
- W2387496161 hasPublicationYear "2014" @default.
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