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- W2387496661 abstract "We analyzed the dynamic change of the mRNA expression of Foxp3,CTLA-4 and cytokines in activated antigen specific T cells for learning more mechanism about the specific immune response.The dendritic cell(DC) line D2SC/1 were used as antigen presenting cells(APC) to present OVA_(323-339) to OVA-specific CD4~+T cells divided from DOl 1.10 mouse,an OVA specific TCR transgenic mouse.Cell Counting Kit-8(CCK-8) was used to validate the activated T cell proliferation,while Real time-PCR was performed to evaluate the dynamic change of IL-2,IFN-γ,IL-10,TGF-β,CTLA-4,and Foxp3 mRNA.We found that the optimal dose of the OVA_(323-339) for activating the OVA-specific T cells was 2μmol/L;the peak time of the mRNA expression of IL-2,IFN-γ,IL-10 and TGF-βwere 8,4,2,and 8 h respectively,and Foxp3 mRNA had a temple peak at 2 h and up-regulated again after 24 h.CTLA- 4 mRNA had a high level in un-stimulated T cells,but down-regulated rapidly when T cell activated and maintained the lower level for more than 24 h.The evaluation of the dynamic regulation of the mRNA expression of Foxp3,CTLA-4 and the cytokines may lead us to learn and understand more about the mechanism of adaptive immune response." @default.
- W2387496661 created "2016-06-24" @default.
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- W2387496661 date "2010-01-01" @default.
- W2387496661 modified "2023-09-24" @default.
- W2387496661 title "The dynamic analysis of Foxp3,CTLA-4 and cytokine mRNA expressions in activated antigen-specific T cells" @default.
- W2387496661 hasPublicationYear "2010" @default.
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