Matches in SemOpenAlex for { <https://semopenalex.org/work/W2387498176> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2387498176 abstract "Objective To develop a rapid and sensitive method for the determination of N-tert-butyl-4-[3-( chroname-7-xox) propoxy]benzamide( ZYY-1) in rat plasma by HPLC for pharmacokinetics study. Methods The separation was performed on a Diamonsil ODS C 18 column( 200 mm × 4. 6 mm,5 μm) w ith the mobile phase consisting of acetonitrile-20 mmol·L- 1potassium dihygrogen phosphate( V∶ V = 64∶ 36,adjusted pH to 8. 0 w ith triethylamine). The detective w avelength w as set at 242 nm,the column temperature w as 30 ℃ and the flow rate w as 1. 0 mL·min- 1. The plasma w as prepared by liquid-liquid extraction. Six male rats w ere given a single dose of ZYY-1( 40 mg·kg- 1),and the pharmacokinetics parameters were calculated by DAS 2. 0 softw are. Results The linearity of ZYY-1 w as ranged from 50 μg·L- 1-10 mg·L- 1. The RSD of intra-day and inter-day variations w ere not more than 12. 1%. The main pharmacokinetics parameters for ZYY-1 w ere as follow s: t 1 /2α was( 2. 5 ±1. 8) ×10- 2h,t 1 /2β was( 0. 63 ±0. 53) h,t 1 /2γ was( 36. 4 ±36. 0) h,CL was( 31. 1 ±10. 1) L·h- 1·kg- 1,V was( 9.39 ± 11.2) L·kg- 1,AUC 0-t was( 0. 963 ± 0. 280) mg·h·L- 1. Conclusions This method is simple and sensitive which can be applied to investigate the pharmacokinetics of ZYY-1 in rats." @default.
- W2387498176 created "2016-06-24" @default.
- W2387498176 creator A5037327117 @default.
- W2387498176 date "2014-01-01" @default.
- W2387498176 modified "2023-09-23" @default.
- W2387498176 title "Determination of ZYY-1 in rat plasma: application to a pharmacokinetics study" @default.
- W2387498176 hasPublicationYear "2014" @default.
- W2387498176 type Work @default.
- W2387498176 sameAs 2387498176 @default.
- W2387498176 citedByCount "0" @default.
- W2387498176 crossrefType "journal-article" @default.
- W2387498176 hasAuthorship W2387498176A5037327117 @default.
- W2387498176 hasConcept C112705442 @default.
- W2387498176 hasConcept C113196181 @default.
- W2387498176 hasConcept C178790620 @default.
- W2387498176 hasConcept C179998833 @default.
- W2387498176 hasConcept C185592680 @default.
- W2387498176 hasConcept C2777463227 @default.
- W2387498176 hasConcept C2780231548 @default.
- W2387498176 hasConcept C2781283055 @default.
- W2387498176 hasConcept C43617362 @default.
- W2387498176 hasConcept C4725764 @default.
- W2387498176 hasConcept C71240020 @default.
- W2387498176 hasConcept C71924100 @default.
- W2387498176 hasConcept C98274493 @default.
- W2387498176 hasConceptScore W2387498176C112705442 @default.
- W2387498176 hasConceptScore W2387498176C113196181 @default.
- W2387498176 hasConceptScore W2387498176C178790620 @default.
- W2387498176 hasConceptScore W2387498176C179998833 @default.
- W2387498176 hasConceptScore W2387498176C185592680 @default.
- W2387498176 hasConceptScore W2387498176C2777463227 @default.
- W2387498176 hasConceptScore W2387498176C2780231548 @default.
- W2387498176 hasConceptScore W2387498176C2781283055 @default.
- W2387498176 hasConceptScore W2387498176C43617362 @default.
- W2387498176 hasConceptScore W2387498176C4725764 @default.
- W2387498176 hasConceptScore W2387498176C71240020 @default.
- W2387498176 hasConceptScore W2387498176C71924100 @default.
- W2387498176 hasConceptScore W2387498176C98274493 @default.
- W2387498176 hasLocation W23874981761 @default.
- W2387498176 hasOpenAccess W2387498176 @default.
- W2387498176 hasPrimaryLocation W23874981761 @default.
- W2387498176 hasRelatedWork W2187906262 @default.
- W2387498176 hasRelatedWork W2235102258 @default.
- W2387498176 hasRelatedWork W2362310846 @default.
- W2387498176 hasRelatedWork W2364075173 @default.
- W2387498176 hasRelatedWork W2376876427 @default.
- W2387498176 hasRelatedWork W2400011979 @default.
- W2387498176 hasRelatedWork W2412279906 @default.
- W2387498176 hasRelatedWork W2440987822 @default.
- W2387498176 hasRelatedWork W2557914176 @default.
- W2387498176 hasRelatedWork W2741774619 @default.
- W2387498176 hasRelatedWork W2760721876 @default.
- W2387498176 hasRelatedWork W2808567898 @default.
- W2387498176 hasRelatedWork W3032192085 @default.
- W2387498176 hasRelatedWork W3032739570 @default.
- W2387498176 hasRelatedWork W2181409626 @default.
- W2387498176 hasRelatedWork W2466370907 @default.
- W2387498176 hasRelatedWork W2518970480 @default.
- W2387498176 hasRelatedWork W2894119203 @default.
- W2387498176 hasRelatedWork W2943668692 @default.
- W2387498176 hasRelatedWork W3032039810 @default.
- W2387498176 isParatext "false" @default.
- W2387498176 isRetracted "false" @default.
- W2387498176 magId "2387498176" @default.
- W2387498176 workType "article" @default.