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- W2387518230 abstract "Objective To investigate the effects of thoracic epidural anesthesia (TEA) with lidocaine on stroke volume variation and hemodymics in patients undergoing general anesthesia (GA), and to explore the mechanism of hypotension. Methods Forty patients of American Society of Anesthesiologists (ASA) class Ⅰ or Ⅱ, undergoing scheduled stomach operation, were randomized into TEA+GA group (n=20, group C) and general anesthesia group (n=20, group G ). Epidural catheter was placed in T9 to T12 before induction of general anesthesia in group C. Ringer lactate solution of 10 mL/kg was infused intravenously in all patients before induction of anesthesia; and it was maintained at 10 mL·kg-1·h-1 thereafter. After induction of anaesthesia, a left radial arterial cannulation and a right internal jugular catheter were placed for continuous monitoring of the stroke volume variation (SVV), cardiac output (CO), stroke volume (SV), mean arterial pressure (MAP), central venous pressure (CVP) and systemic vascular resistance (SVR). Four milliliter 2% lidocaine was given through epidural catheter in group C. All parameters were observed at 5th, 10th, 15th and 20th min after epidural injection in group C and in group G. Results There was no significant difference in HR, CVP, CO and SV at each time point between group C and group G (P0.05). No significant change was found in MAP and SVR in group G at each time point (P0.05), but the 2 indices were significantly declined in group C after epidural lidocaine (P0.05), even lower than those in group G (P0.05). SVV was increased slightly from baseline in group C at 5 to 20 min after epidural lidocaine (P0.05), but it was gradually declined in group G. There were significant differences in SVV between the 2 groups at all time points (P0.05). Conclusion The decline of SVR is the main reason of hypotension in epidural block combined with general anesthesia. The hypovolume is the secondary factor." @default.
- W2387518230 created "2016-06-24" @default.
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- W2387518230 date "2011-01-01" @default.
- W2387518230 modified "2023-09-23" @default.
- W2387518230 title "Effect of epidural block combined with general anesthesia on hemodynamics" @default.
- W2387518230 hasPublicationYear "2011" @default.
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