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- W2387524888 abstract "Objective: To study the effects of intrathecal coadministration of morphine and ketamine on plasma β-endorphin and thermal hyperalgesia of rats with sciatic constriction injury. Methods: Male Wistar rats, weighting 220～260g with a peripheral mononeuropathy produced by placing loosely constrictive ligatures around the common sciatic nerve, were randomly divided into 4 groups (8 animals each group). Another 8 normal rats without any treatment were group B. Group C received intrathecal 0.9% NaCl 10μl, group K ketamine 50μg, group M morphine 20μg, group KM morphine 10μg plus ketamine 25μg. The volume of the injected solution was 10μl, and the catheters were flushed with normal saline 10 μl, once a day for 7 days. Changes in paw withdrawl latency(PWL) to heat stimulus were measured at 30min after injection everyday. Blood (2ml) were obtained form the animals killed after 7days, plasma β-endorphin were measured by radioimmunoassay. Results: (1) The changes in PWL in group KM and M were significantly higher than that in group C and K ( P 0.01),but with time went on, the effect of analgesia in group M was decreased gradually. There were significant differences between group M and group KM on day 6 and 7 ( P 0.05 P 0.01). Analgesia in group K was significantly higher than that in group C( P 0.01). (2)β-endorphin of the plasma in group C and in group M were significantly lower than that in group B( P 0.01) and in group KM( P 0.05). Conclusion: Morphine plus ketamine administered intrathecally can antagonize thermal hyperalgesia better than morphine or ketamine done. The level of plasma β-endorphin might somehow reflect the intensity of neuropathic pain." @default.
- W2387524888 created "2016-06-24" @default.
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- W2387524888 date "2004-01-01" @default.
- W2387524888 modified "2023-09-25" @default.
- W2387524888 title "EFFECTS OF INTRATHECAL COADMINISTRATION OF MORPHINE AND KETAMINE ON PLASMA β-ENDORPHIN IN RATS WITH SCIATICA" @default.
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