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- W2387531056 abstract "【Objective】 To study the effect L-T4 replacement therapy to carotid artery intima-media thickness(IMT).【Methods】Carotid artery IMT and lipoprotein profile were assessed in 45 Subclinical hypothyroidism(sHT) patients at baseline and after 6 months L-T4 replacement with comparison to 45 age-and sex-matched controls.【Results】sHT patients had elevated total and low-density lipoprotein(LDL) cholesterol and ApoB levels and higher mean-IMT values.In stepwise regression analysis,mean-IMT was positively related to LDL cholesterol and TSH.L-T4 replacement significantly reduced both total and LDL cholesterol and mean-IMT.The decrement in IMT was directly related to the decrements of both total cholesterol and TSH.【Conclusions】The fact that both the atherogenic lipoprotein profile and intima-media thickening were improved by L-T4 replacement therapy suggests that lipid infiltration of arterial wall may represent an important mechanism underlying IMT increase in subclinical hypothyroidism." @default.
- W2387531056 created "2016-06-24" @default.
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- W2387531056 date "2008-01-01" @default.
- W2387531056 modified "2023-09-25" @default.
- W2387531056 title "Effect of levothyroxine replacement on intima-media thickness in subclinical hypothyroidism" @default.
- W2387531056 hasPublicationYear "2008" @default.
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