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- W2387546031 abstract "Objective To explore the proliferation inhibiting and apoptosis inducing effect of vincristine on human osteosarcoma MG63cells and clarify the molecular mechanisms.Methods Cell number counting were determined with CCK8and cell apoptosis were determined with Hoechest 33342,respectively in MG63cells which explored on different concerntrations of vincristine(0,5,10,20,50,100μg·L-1).Real time quantitative RT-PCR was used to analyze gene expression.Results 10μg.L-1 vincristine could significantly inhibit the proliferation of MG63cells(P0.05),the apoptotic cells increased with the increasing of concentration of vincristine;vincristine decreased the expression of c-myc gene(P0.05)and increased the expression of caspase9gene(P0.05).Discussion:Vincristine can inhibit the proliferation and promote the apoptosis of MG63cells with low concentration,its mechanism is to down-regulate the c-myc and up-regulate the caspase9." @default.
- W2387546031 created "2016-06-24" @default.
- W2387546031 creator A5051894569 @default.
- W2387546031 date "2013-01-01" @default.
- W2387546031 modified "2023-09-24" @default.
- W2387546031 title "Proliferation inhibiting and apoptosis inducing effect of vincristine on MG63 cells and the mechanisms involved" @default.
- W2387546031 hasPublicationYear "2013" @default.
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