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- W2387560170 abstract "Objective Detecting the level of thrombopoietin and the percentage of T lymphocyte subsets and platelet associated antibody in the patients with idiopathic thrombocytopenic purpura(ITP),to investigate their pathogenesis and clinical significance.Methods The level of thrombopoietin and the percentage of T lymphocyte subsets and platelet associated antibody in 50 ITP patients and 24 healthy controls were tested by virtue of sandwich enzyme-linked immunosorbent assay and flow cytometry respectively.Results Compared with the controls(226.63±45.63×109/L),the counts of platelets in ITP patients(30.65±18.34×109/L,P0.05).However,there was no apparent difference of the level of thrombopoietin between ITP patients and health controls(76.65±32.50 pg/ml,71.62±23.03 pg/ml respectively,P 0.05).In T lymphocyte subsets,the percentage of CD 3+ T lymphocyte and CD 4+ T lymphocyte and the ratio of CD 4+/CD 8+ in patients with ITP(60.06±12.08%,27.74±9.67%,1.11±0.34% respectively) were notably decreased than those healthy controls(of which those of control group were 69.89±5.56%,35.87±4.07%,1.64±0.32% respectively,P 0.05),but the percentage of CD 8+ T lymphocyte was significantly elevated(which were 31.12±12.49% and 22.53±4.12% respectively,P 0.05).The percentage of PAIgG,PAIgM,PAIgA were apparently increased in ITP patients(which were 27.19±17.43%,41.15±15.62% and 33.18±16.37%)than health controls(which were 9.28±3.85%,16.78±9.26%,22.12±8.86%,all P0.05).Conclusion Thrombopoietin with T lymphocyte subsets and platelet associated antibody in the patients with ITP,were reflect the pathogenesis of ITP,could be able to improve the diagnosis and guide clinical therapy." @default.
- W2387560170 created "2016-06-24" @default.
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- W2387560170 date "2009-01-01" @default.
- W2387560170 modified "2023-09-26" @default.
- W2387560170 title "Detection of Thrombopoietin and Platelet Associated Antibody in the Patients with Idiopathic Thrombocytopenic Purpura" @default.
- W2387560170 hasPublicationYear "2009" @default.
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