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- W2387568314 abstract "Objective To investigate the anticancer activities and mechanisms of bufalin in the orthotopic transplantation model of human colon cancer in nude mice.Methods Orthotopic transplantation tumor models of human colon cancer HCT-116 cells in nude mice were treated with different dose of bufalin(0.5,1.0 and 1.5 mg/kg),using normal saline treatment(NS 0.2 mL each mouse) as negative control groups(NS group) and 5-FU(25 mg/kg) as the positive control groups(5-FU group).The tumors were measured and the rates of tumor inhibition were calculated.The necrotic degree of orthotopic transplanted tumor was observed by hematoxylin-eosin staining.The apoptotic index of tumor cell was measured by TUNEL staining.The expression level of apoptosis-regulated gene Caspase-3 in tumor tissues was detected by real-time fluorogenic quantitative polymerase chain reaction(RFQ-PCR),immunohistochemical method and Western-blot.Results The tumor volume of each bufalin group and the 5-FU group reduced significantly compared with that of NS group(P 0.05).The median survival time of NS group,5-FU group and three bufalin groups were 40,37,47,46 and 45 days.The survival days of each bufalin group prolonged compared with that of NS group(P0.05).The necrotic degree increased in 1.0 and 1.5 mg/kg of bufalin groups and the 5-FU group.The apoptotic index in each group of bufalin treatment increased significantly compared with NS group(P0.05).The mRNA and protein expression of Caspase-3 increased in each bufalin group.Conclusions Bufalin has significant anticancer activities in the orthotopic transnplantation model of human colon cancer in nude mice.It induces apoptosis of transplanted tumor cells.The mechanism may be associated with the up-regulation of Caspase-3 in tumor cells." @default.
- W2387568314 created "2016-06-24" @default.
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- W2387568314 date "2013-01-01" @default.
- W2387568314 modified "2023-09-25" @default.
- W2387568314 title "Effects of bufalin on Caspase-3 expression in the nude mice with orthotopic transplantation of colon cancer" @default.
- W2387568314 hasPublicationYear "2013" @default.
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