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- W2387580274 abstract "Purpose To explore the clinicopathologic characteristics and therapeutic methods of small cell neuroendocrine carcinoma of prostate.Methods Three cases of prostate small cell neuroendocrine carcinoma were diagnosed during 1999 to 2011 in the General Hospital of PLA,and the clinicopathological data of the 23 cases summarized,which were collected from the Chinese literature from 1999 to 2011.The overall survival and correlations between different clinicopathologic characteristics were analyzed.Results Patients ranged in age from 21 to 82 years old(mean 59 years).18(69.2%) patients showed dysuria,9(34.6%) patients showed urinary irritation symptoms and 6(23.1%) patients showed hematuria.Serum PSA lever increased in 20(76.9%) patients and it was normal in 6(23.1%) patients.5(19.2%) cases were mixed and and 21(80.8%) were pure in morphology.14(53.8%) cases underwent needle biopsies,5(19.2%) transurethral resections,and 7(26.9%) radical prostatectomies.Postoperative therapy included endocrine therapy(12,46.2%),chemical therapy(10,38.5%) and radiotherapy(2,7.7%).There were local invasion(12,46.2%),lymph and vessel invasion(8,30.8%),and distant metastasis(9,34.6%) when diagnosis.The longest follow-up was 17 months.16(61.5%) were died,8(30.8%) were lived at the time of follow-up,and 2(7.7%) were lost of follow-up.The median survival was 8 months,and 1 year survival rate was 23.2%.The survival was significantly correlated with chemotherapy(P0.05),but serum PSA level,surgical procedures,pathological types,therapies,local invasion,lymph vessel invasion,and distant metastasis had no significant relationship with survival statistically(P0.05).Conclusions Small cell neuroendocrine carcinoma of prostate is a rare neoplasm with high malignancy,metastasizing early and poor prognosis,and 1 year survival rate was 23.2%.Its diagnosis is relied on pathological examinations.The serum PSA level is usually normal in pure cases.Surgery,mixed histology with acinar adenocarcinoma components and the clinical stage had no relationship with the prognosis.Chemotherapy is the only prognostic factor.To the patients diagnosed with biopsy preoperatively,chemotherapy should be suggested as first line of treatment to improve the prognosis." @default.
- W2387580274 created "2016-06-24" @default.
- W2387580274 creator A5066209214 @default.
- W2387580274 date "2013-01-01" @default.
- W2387580274 modified "2023-09-23" @default.
- W2387580274 title "Clinicopathologic characteristics of prostate small cell neuroendocrine carcinoma" @default.
- W2387580274 hasPublicationYear "2013" @default.
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