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- W2387597216 abstract "Objective To investigate the effect of dopamine beta-hydroxylase(DBH) gene intron 5 TaqⅠdigestion polymorphism on the mechanism of tourette syndrome(TS) in Han population in Tianjin.Methods Genotypes distribution and allele frequency of DBH gene intron 5 TaqⅠdigestion polymorphism were examined in 106 TS patients and 80 normal subjects by using polymerase chain reaction-restriction frag-ment length polymorphism(PCR-RFLP) technique.Genotypes distribution and allele frequency were calculat-ed and compared.Results No significant differences were found between TS patients and normal subjects in the genotypes distribution and allele frequency of DBH gene intron 5 TaqⅠdigestion polymorphism(P 0.05,for all).Further more,the distribution of A2 /A2 genotype and frequency of A2 allele in TS with attention deficit hyperactivity disorder(ADHD) patients were higher than those in TS without ADHD patients and nor-mal subjects(P 0.05,for all),but no significant differences were found between TS without ADHD patients and normal subjects(P 0.05,for all).Related analysis showed that A2 allele significantly increased the risk of suffering ADHD in TS patients by 2.91(OR = 2.905,95%CI:1.313-6.929,P = 0.009).Conclusion DBH gene intron 5 TaqⅠ digestion polymorphism is not probably associated with TS patients in Han population in Tianjin,but A2 allele may probably increase the susceptibility of ADHD in TS patients." @default.
- W2387597216 created "2016-06-24" @default.
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- W2387597216 date "2009-01-01" @default.
- W2387597216 modified "2023-09-23" @default.
- W2387597216 title "Study on the dopamine beta-hydroxylase gene TaqI digestion polymorphism and tourette syndrome:a case-control study" @default.
- W2387597216 hasPublicationYear "2009" @default.
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